Romanian Journal of Oral Rehabilitation Numarul 2 STUDY ON THE EFFECTS OF MELATONIN ADMINISTRATION ON INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN PATIENTS WITH TYPE II DIABETES AND PERIODONTAL DISEASE

STUDY ON THE EFFECTS OF MELATONIN ADMINISTRATION ON INFLAMMATORY AND OXIDATIVE STRESS MARKERS IN PATIENTS WITH TYPE II DIABETES AND PERIODONTAL DISEASE

Diana-Maria Anton, Irina-Georgeta Sufaru, Maria-Alexandra Martu, Raluca Mocanu, Ionut Luchian, Monica-Mihaela Scutariu, Liliana Pasarin, Silvia Martu

Abstract:

The aim of this study was to evaluate the effects of melatonin supplementation accompanied by non-surgical periodontal therapy on serum melatonin, as well as inflammatory and oxidative stress markers in patients with type 2 diabetes with chronic periodontitis. The study was conducted on 50 subjects with periodontitis and diabetes mellitus type 2 (study group n = 25: patients with scaling and root planing + melatonin; control group = 25: patients with scaling and root planing + placebo). The melatonin, interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-α) and high-sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC) and total serum oxidant (TOS) levels were measured at baseline and after 8 weeks. Melatonin systemic intake reduced inflammation and oxidative stress markers in diabetic patients with chronic periodontitis.

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