Romanian Journal of Oral Rehabilitation Numarul 1 COMPARISON OF BLEEDING RISKS WITH NEW ORAL ANTICOAGULANTS VERSUS ACENOCUMAROLUM – part 2

COMPARISON OF BLEEDING RISKS WITH NEW ORAL ANTICOAGULANTS VERSUS ACENOCUMAROLUM – part 2

Roxana Radu, Octavian Dincă, Cristina Pădurariu, Tiberiu Niță, Cristian Vlădan, Alexandru Bucur

ABSTRACT

Aim of the study

Oral anticoagulants have been used to prevent first or recurrent stroke, especially among patients with arterial fibrillation and y atherosclerotic disease. Despite the widespread use in dental patients, safety of anticoagulants are controversial. The uncertainty is due to the lack of definitive clinical data. In the present review, we have attempted to compare the relationship between the risk factors and postoperative hemorrhage after tooth extraction among patients with recent stroke receiving acenocumarolum versus new oral anticoagulants users.

Material and methods  This is a retrospective study of all patients exposed to oral anticoagulants who required tooth extraction treated in Clinic of Oral and Maxillofacial Surgery, Carol Davila University Bucharest – Hospital of Oral and Maxillofacial Surgery from 2019 to 2020. Clinical and operative records of all patients were retrieved and reviewed from the hospital’s medical records. All data were analyzed using Stata/IC 16 software (StataCorp). Ethical approval from the local institutional ethics comitee was obtained for this study.

Results In our study, there were no significant differences between continuous oral anticoagulation use prescribd for antecedents of stroke and bleeding rate (32.14% vs. 20.92%, p > 0,05). Additionally, post-extraction bleeding was statistically significant associated with the type of anticoagulant used among concomitant diabetes patients.

Conclusions

In patients with prior cerebrovascular accident, concomitant use of new oral anticoagulants was associated with increased risk of postoperative bleeding. Concomitant diabetes contribute to the risk of bleeding.

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