Romanian Journal of Oral Rehabilitation Numarul 1 COMPARISON OF BLEEDING RISKS WITH NEW ORAL ANTICOAGULANTS VERSUS ACENOCUMAROLUM – part 1

COMPARISON OF BLEEDING RISKS WITH NEW ORAL ANTICOAGULANTS VERSUS ACENOCUMAROLUM – part 1

Roxana Radu, Octavian Dincă, Cristina Pădurariu, Tiberiu Niță, Cristian Vlădan, Alexandru Bucur

ABSTRACT

Aim of the study Oral anticoagulants are effective therapies for reduction of stroke risk in patients with atrial fibrillation. However, blocking elements of the clotting cascade carries an inherent risk of bleeding. Also, anticoagulated patients sometimes require tooth extractions and other invasive procedures. The purpose of the present study was to compare the relationship between the risk factors and postoperative hemorrhage among dental patients with atrial fibrillation receiving acenocumarolum versus new oral anticoagulants users.

Material and methods A sample of consecutive patients exposed to oral anticoagulants who required tooth extraction at our institution were retrospectively reviewed. Categorical data are summarized as percentages, and differences between groups were tested using Stata/IC 16 software (StataCorp). Ethical approval from the local institutional ethics comitee was obtained for this study.

Results The overall bleeding rate was higher in new anticoagulant users than in acenocumarolum users (26.72% vs 12%, p = 0.03) and similar (17.8% vs 14.1%, p = 0.129) between the two groups. There were no significant differences between atrial fibrillation patients and non-atrial fibrillation patients regarding bleeding rate. The highest rates were observed in patients with congestive cardiac failure exposed to new oral anticoagulants.

Conclusions According to the results of our study, patients exposed to new oral anticoagulants had  higher rates of overall bleeding events than chronic acenocumarolul users.

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