Carmen Gabriela Stelea, Emilia Dîmbu, Sorin Andrian, Oana Elena Ciurcanu, Alexandra Lorina Stelea, Cristina Bologa
Aim of the study: The management of patients undergoing chronic oral anticoagulation raises concerns regarding the postoperative bleeding risk. In the last few years, new oral anticoagulants were released on the market, but the operative protocols for dental surgery interventions are still not well established. The purpose of this review is to summarize the articles` evidence that evaluate the risk of bleeding with the use of Direct Oral Anticoagulants (DOACs). Material and methods: A systematic literature search was conducted from January 2014 to June 2018, in PubMed, Science Direct, Web of Science and Scopus databases. Results: Six articles met the inclusion criteria, all being observational studies. Conclusions showed that dental surgery could be performed without cessation of the DOACs, with a low incidence of bleeding complications, by applying local haemostatic measures (suturing, haemostatic agents, compression with sterile gauzes soaked in 5% tranexamic acid or the use of mouthwash with 5% tranexamic acid).