RJOR - Official publication of Romanian Association of Oral Rehabilitation

Str. Mihail Kogalniceanu No.2, Iasi, Romania



Romanian Journal of Oral Rehabilitation 2012,Numarul 4 Immunohistochemical Aspects In Pleomorphic Adenoma, Related To Its Histogenesis And Malignization

Immunohistochemical Aspects In Pleomorphic Adenoma, Related To Its Histogenesis And Malignization

Mioara Trandafirescu, Constantin Cotutiu, Elena Cojocaru, Liliana Foia

Known and described since the nineteenth century as mixed tumour of salivary gland, and subsequently called pleomorphic adenoma, this tumour is a benign lesion with a complex structure, composed of epithelial type areas mixed with fibrous, mucoid or condroid stromal areas. The lesion raised many discussions related to its histogenesis and its possibility of malignancy, talks which currently continue. In order to argue for some of the theories, immunohistochemical reactions with anti-cytokeratin, anti-vimentin, anti-S100 protein, anti-p53 protein, anti-Ki67 protein, and anti-CD34 monoclonal antibodies were used. It was noted that all the cellular components of the lesion respond positively to cytokeratin and vimentin, more intensely in myoepithelial cells and periductular cells. All the proliferation markers were positive in all the cells, regardless of the morphological type and the intensity was increased in cases of malignancy. Thus, our research supports the hypothesis of the unique epithelial histogenesis and the possibility of malignization of pleomorphic adenoma, which differs from the primitive salivary gland carcinomas.

Download (PDF, 679KB)

Tags: , , ,

By continuing to use the site, you agree to the use of cookies || Prin continuarea navigarii pe acest site esti de acord cu utilizarea cookie-urilor more information || mai multe informatii

RJOR.RO utilizeaza fisiere de tip cookie pentru a personaliza si imbunatati experienta ta pe Website-ul nostru. Te informam ca ne-am actualizat politicile pentru a integra in acestea si in activitatea curenta a adre.ro cele mai recente modificari propuse de Regulamentul (UE) 2016/679 privind protectia persoanelor fizice in ceea ce priveste prelucrarea datelor cu caracter personal si privind libera circulatie a acestor date. inainte de a continua navigarea pe Website-ul nostru te rugam sa aloci timpul necesar pentru a citi si intelege continutul Politicii de Cookie. Prin continuarea navigarii pe Website-ul nostru confirmi acceptarea utilizarii fisierelor de tip cookie conform Politicii de Cookie. Nu uita totusi ca poti modifica in orice moment setarile acestor fisiere cookie urmand instructiunile din Politica de Cookie The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.